In a recent achievement, DP Technology's hit discovery platform RiDYMO® has successfully designed a cyclic peptide targeting β-catenin, a historically "undruggable" protein, in just two months.

Breakthrough in creating cyclic peptide opens the way for new antibiotics Date: June 10, 2024 Source: King's College London Summary: A discovery could speed up efforts to produce new antibiotics ...

That cyclic shape provides a greater surface area for peptides to disrupt the deleterious protein-to-protein interactions that drive diseases, and the cyclic structure’s stability helps the ...

Yet modifying or designing antibiotics to evade resistance is challenging due to the complexity of their molecular structure. Some are formed of cyclic peptides – strings of amino acids joined ...

Caspofungin, micafungin, and anidulafungin all belong to the cyclic hexaliphatic peptide family. They share the same cyclic peptide core structure and are cyclized by amidation between the n-end of ...

Oral peptides: A new era in drug development Date: January 9, 2024 Source: Ecole Polytechnique Fédérale de Lausanne Summary: Scientists have developed stable orally available cyclic peptides ...

A dreaded fungus known to inhabit tombs has been reconstituted as a treatment for leukemia and is performing as effectively ...

Moreover, cyclic peptides exhibit strong lipophilicity, ... By optimizing the peptide's size and side chain structure, they identified DC646 as the most potent FXR antagonist, ...

Antonis Rokas, a fungal biologist at Vanderbilt University who was not affiliated with the study, calls the work a tour de ...

The protein uses copper and oxygen to form cyclic peptides. We can investigate how this chemistry occurs more thoroughly now that we know what the protein structure looks like. Credit: Nature ...

Cyclic peptides derived from flaxseed, commonly known as cyclolinopeptides or linusorbs, represent a unique class of naturally occurring bioactive compounds. Their cyclic structure confers ...

Considering that orally administered cyclic peptides generally show a bioavailability below 2%, an oral bioavailability of 18% is a substantial advance for peptide-based biologic drugs.