Agre went on to establish the family of related channels, which he named "aquaporins." Solving the structure of these channels provided a platform for exploring the underlying molecular mechanisms ...

The structure showed that the protein forms a channel in the membrane that is 2 nanometers (billionth meter) long and 0.3 nanometers wide, just large enough for water molecules to fit through ...

Aquaporins in the lung. Water homeostasis is a crucial element of numerous pathophysiological processes that occur in the respiratory tract ( Box 2 ), and a network of aquaporins is present in ...

STRUCTURE OF A SIEVE. These newly discovered channels displayed some intriguing properties. For example, while highly permeable to water, aquaporins prevent other small molecules, such as urea, ions, ...

Detailed analyses of Plasmodium falciparum aquaporin structure and homologs were compared with those of humans. The feasibility of using aquaporins as potential sites of anti-protozoan ...

A number of aquaporins, including aquaporin-1, have been found to function as ion channels, ... The scientists report their findings in the September issue of the journal Structure.

In the natural world, aquaporins rapidly shuttle water molecules into and out of cells and mimicking this function could help improve the production of chemicals and pharmaceuticals. KAUST researchers ...

Aquaporins are selective water channels that enable rapid water transport across ... We propose that the answer to this question might reside in the homotetrameric structure of aquaporins, ...

Aquaporins form a large, diverse family of proteins and have been found in bacteria, plants, and animals. Less than a decade ago, scientists discovered the aquaporin Z gene (aqpZ) in E. coli ...

What does a review of the literature indicate about aquaporins found in Apicomplexan, Kinetoplastida, and Microsporidia parasites as potential drug targets? News & Perspective Drugs & Diseases ...