Pitavastatin is a synthetic HMG-CoA reductase inhibitor with a novel cyclopropyl moiety. This structural innovation means that pitavastatin binds avidly to and potently inhibits, HMG-CoA reductase.

Some statins work best in the evening, while others work just as well in the morning. The best time to take statins depends ...

HMG-CoA reductase inhibitors (statins) are the mainstay of dyslipidemia management. A meta-analysis of 14 studies estimated that the mean LDL-C reduction following 1 year of statin treatment ...

By inhibiting the production of HMG-CoA reductase, statins slow the synthesis not only of cholesterol, but also of a number of molecules called isoprenoids, which are involved in many aspects of ...

High cholesterol can be reduced by eating certain foods. A British Heart Foundation cardiologist has shared the two foods ...

In this valuable study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, ...

Scientist Development Grant, American Heart Association National Center, for “Mechanisms of eNOS phosphorylation and activation by HMG-CoA reductase inhibitors,” 1/1/04-12/30/07 Individual National ...

Statins may limit inflammation involved in the development of these complications. Objectives We tested the hypothesis that perioperative simvastatin use reduces postoperative cardiopulmonary ...