More information: Highly potent quinoxalinediones inhibit a-hemolysin and ameliorate Staphylococcus aureus lung infections, Cell Host & Microbe (2025). DOI: 10.1016/j.chom.2025.03.006 . www.cell ...

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution. Cell Reports , 2020; 33 (2): 108247 DOI: 10.1016/j.celrep ...

The research is published in the paper, “Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution,” in Cell Reports ...

Pneumonia caused by the bacterium Staphylococcus aureus is one of the most dangerous ... The new research approach is aimed at the targeted inhibition of the key virulence factor α-hemolysin.

Article Title. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections ...

Control of infection with Staphylococcus aureus relies on the production of neutrophil-recruiting chemokines by perivascular macrophages. S. aureus counterattacks by secreting α-hemolysin, which ...

This downregulation resulted in decreased ability of the bacteria to adhere to host cells, and reduced S. aureus toxin-mediated hemolysis and thrombolysis of host cells.

Bacterial protein serves as sensor Date: June 10, 2015 Source: Albert-Ludwigs-Universität Freiburg Summary: A method capable of precisely measuring the size of individual molecules has been ...

As the research team reports in the current issue of the specialist journal “Cell Reports”, the toxic cocktail with which Staphylococcus aureus damages cells and tissues also has positive effects: ...

04/01/2025 10:17 New agent inhibits Staphylococcus aureus toxin – hope for pneumonia patients Dr. Andreas Fischer Presse und Kommunikation Helmholtz-Zentrum für Infektionsforschung. Helmholtz ...