The study revealed that people with these genetic changes were found to be more than twice as likely to develop heart failure ...

Background Although treatment options for heart failure (HF) have improved, advanced HF (AdHF) remains a challenging ...

Background An increase in myocardial collagen content may contribute to the development of heart failure; this might be inhibited or reversed by mineralocorticoid receptor antagonists (MRAs). We ...

The Eli Lilly drug caused a major drop in the blood levels of Lp(a), but further research is needed to show that it will prevent heart attacks and strokes.

Spironolactone is being used widely in HF without consideration of the NYHA class and ejection fraction, and without optimization of background treatment with angiotensin-converting enzyme inhibitors.

Spironolactone – sometimes called “spiro” for short – has been a miracle drug for many suffering from acne, PCOS, and hair loss. Typically taken orally or in combination with other topical treatments, ...

Among heart attack survivors without heart failure who were on "very good" background medical therapy, routine spironolactone was no better than placebo regarding the trial's two coprimary ...

More research is needed to further explore the potential for spironolactone, a blood pressure medication, to prevent heart failure and its long-term impact on an individual’s heart health after ...

Research Highlights: The CLEAR SYNERGY trial found that spironolactone may reduce the risk of new or worsening heart failure; however, it did not significantly impact the rate of death, new heart ...

“Routine spironolactone post-MI did not reduce either of our coprimary outcomes,” Jolly said at the press conference. “We did see about a one-third reduction in new or worsening heart failure.

Spironolactone, a potassium-sparing diuretic typically used to treat heart failure and hypertension, has shown promise for alcohol use disorder, a common condition with few treatment options.

A generic drug used for decades to treat heart failure and high blood pressure shows early potential as a treatment for alcohol use disorder, a new study suggests. The pill, spironolactone, costs ...