The success of Vertex's opioid alternative Journavx could aid a group of biotechs that aim to take a similar path with NaV1.8 ...

Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

Sodium hypochlorite is the most used irrigating solution in endodontics, because its mechanism of action causes biosynthetic alterations in cellular metabolism and phospholipid destruction, formation ...

The exact mechanism of the hypotensive action of chlorothiazide is not yet clear. In some publications it is claimed to be independent of the simultaneous natriuretic effect of the drug.

Mechanism of action of the hepatitis B and D virus cell entry inhibitor bulevirtide deciphered. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2024 / 04 ...

Introduction. Sodium hypochlorite (NaOCl) is the most used irrigant in endodontic treatment 1, due to its antimicrobial 2 and tissue dissolution 3 action, being used in concentrations between 0.5% - 6 ...

Studies to elucidate the mode of action of aldosterone have been carried out in the amphibian urinary bladder. The following previously reported hypotheses were evaluated: (1) aldosterone stimulates ...

Sodium hypochlorite extrusion is mainly related to misuse of the compound, irregularities of the root canal system, wide apical foramen diameter [8], and using liquid form [9]. Endodontic treatment of ...

Sodium-Glucose Cotransporter 2 inhibitors (SGLT2i), or gliflozins, are a group of antidiabetic drugs that have shown improvement in renal and cardiovascular outcomes in patients with kidney disease, ...

Citation: Pesti K, Földi MC, Zboray K, Toth AV, Lukacs P and Mike A (2021) Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism ...