By contrast, type II EC, which includes uterine serous cancer (USC), clear cell cancer and grade 3 endometrioid carcinoma, typically occurs in older, thinner patients and is not hormone dependent.

Expert Rev Anticancer Ther. 2012;12(1):41-49. Uterine serous cancer (USC) is a highly aggressive variant of endometrial cancer. USC is resistant to cytotoxic chemotherapy and is responsible for ...

Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were ...

Uterine cancer incidence and mortality rates are projected to increase significantly through 2050, according to a study ...

The vaginal smear for the diagnosis of cancer of the uterus was introduced by Papanicolaou in 1928. Its value is based on the fact that carcinomatous lesions of the cervix and endometrium are ...

Endometrial Cancer Stages After being diagnosed with endometrial cancer, doctors will try to figure out if it has spread and, if so, how far. This process is called staging. The stage of a cancer ...

In this open-label, single-arm phase 2 study, women (aged ≥18 years) with recurrent low-grade serous ovarian or peritoneal carcinoma were given selumetinib (50 mg twice daily, orally) until ...

Using novel mouse models, we establish cyclin-dependent kinase 12 (CDK12) as a bona fide tumor suppressor gene in tubo-ovarian high-grade serous carcinoma, demonstrating that its loss drives increased ...

Treatment options for patients with platinum-resistant ovarian cancer include non-platinum chemotherapy administered alone or with bevacizumab. 2 Weekly paclitaxel is considered the most active ...