Activation of lung fibroblasts and differentiation to myofibroblasts are the principal effectors of disease pathology, but damage and senescence of alveolar epithelial cells, specifically type II ...

Breast cancer often relapses in distant organs even when complete regression of primary tumors is achieved after initial ...

To examine the role of gap junctions in cell senescence, the changes of gap junctions in cisplatin-induced premature senescence of primary cultured fibroblasts were studied and compared with the ...

Fibroblasts produce the internal scaffolding that give skin tissues their structure. They pushed the fibroblasts towards senescence by damaging their DNA, which happens with aging.

A new research paper was published in Aging's Volume 16, Issue 13, entitled, “Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells.” ...

A new research paper was published on the cover of Aging's Volume 16, Issue 4, entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” ...

The phenomenon of oncogene-induced senescence was first described in primary cultured murine fibroblasts ectopically expressing mutant RAS alleles (Serrano et al., 1997). It is now generally ...

Cell senescence was first identified by Leonard Hayflick and Paul Moorhead in 1961, when they serially passaged human fibroblast cells in culture. 3 They noticed that the cells stopped dividing after ...

Cellular senescence of cancer-associated fibroblasts play a key role in peritoneal dissemination. Download PDF Copy; Reviewed. Reviewed by Emily Henderson, B.Sc. Mar 23 2021.

Since AP2A1 upregulation was observed in different types of senescence (replicative, UV-induced, and drug-induced) and in ...

Senescence was induced in normal colon fibroblasts isolated from colorectal rectal cancer patients resected from normal adjacent tissue. Senescence associated secretory phenotype (SASP) factors were ...