This partially assembled SNARE complex locks the C-terminal (CTD ... provide a refined framework for delineating the molecular mechanism of SNARE-mediated membrane fusion and action of regulatory ...

The CD225/Dispanin superfamily contains membrane proteins that regulate vesicular ... Mechanistically, IFITM3 disrupts assembly of the SNARE complex controlling homotypic fusion and accelerates the ...

Subscribe for FREE Membrane fusion is essential for life ... This simulation showed that, rather than just bringing biological membranes together, the SNARE complex induces phospholipids in the cell ...

SNARE-dependent membrane fusion is essential for neurotransmitter release at the ... probe that can detect fusion pores larger than ∼6 nm. We find that the SNARE complex alone is inefficient at ...

and the Sec17 apolar loop has functions beyond membrane anchoring. Thus Sec17 and Sec18 act twice in the fusion cycle, binding to trans-SNARE complexes to accelerate fusion, then hydrolyzing ATP to ...

In the interests of transparency, eLife includes the editorial decision letter and accompanying author responses. A lightly edited version of the letter sent to the authors after peer review is shown, ...

Secretion of neurotransmitters and hormones depends on membrane fusion, accomplished by a cellular fusion machinery whose core components are SNARE proteins. Several vesicle-associated v-SNAREs form ...

Fusion has been thought to occur via the spontaneous zipper-like assembly of the SNARE protein complex, which may distort and pucker the membrane, physically forcing the lipids in the membrane ...

the early rate-limiting step in SNARE complex assembly, and stimulates membrane fusion. The crystal structure of the Sec3-Sso2 complex suggests that Sec3 binding induces conformational changes of ...

It's known that the SNARE complex in yeast forms between two ... a protein complex that tethers a vesicle to the membrane before fusion occurs. After screening the eight subunits of the exocyst ...

Moreover, the regulatory mechanisms by synaptic auxiliary proteins in SNARE-driven membrane fusion are briefly outlined. Figure 1. Topology of the SNARE complex consisting of synaptobrevin (in blue), ...

The luminal C‐termini of these transmembrane domains must approach each other in a small membrane region to open the pore. Example of a simulated hemifusion‐to‐fusion pore transition in the presence ...