Alternative pre-mRNA splicing is a fundamental mechanism of post-transcriptional gene regulation that creates lineage-specific functional diversity in the proteome. Although heart-specific alternative ...

Abstract: A key challenge of image splicing detection is how to localize integral tampered regions without false alarm. Although current forgery detection approaches have achieved promising ...

Abstract: Computing the Voronoi diagram of a given set of points in a restricted domain (e.g., inside a 2D polygon, on a 3D surface, or within a volume) has many applications. Although existing ...

Digital PCR, which simultaneously detects SMN1 gene defects and the number of SMN2 copies to diagnose spinal muscular atrophy (SMA) in newborn screening programs, matches the accuracy of standard ...

An RNA-Seq data exploration tool that shows read map coverage of a gene of interest along with a coloured "electronic fluorescent pictographic" (eFP) based on its RPKM expression level.

Several highly efficient therapeutic options are currently approved for SMA. The therapies are essentially based on two mechanisms: correction of endogenous SMN2 splicing to increase the level of the ...