The function of SIRT1 in cancer is complex: SIRT1 has been shown to have oncogenic properties by downregulating p53 activity, but recent studies indicate that SIRT1 acts as a tumour suppressor in ...

For example, SIRT1 chops off acetyl groups, which can inactivate the tumor suppressor p53. Yuan et al. determined SIRT1's effect on the transcription factor c-Myc, whose expression surges in many ...

In the Hot Papers featured here, several labs made a convincing case that SIRT1 regulates forkhead transcription factors (FOXOs) in mammals. Guarente's group showed that SIRT1 directly deacetylates ...

Changes in the function of p53 are very common in human cancers. miR-34a downregulates the mRNA that codes for Sirt1, a protein that deactivates p53. Using Nuclear Magnetic Resonance ...

Other categories of SIRT1 targets relate to stress tolerance (p53, hypoxia-inducible factor 1α and 2α, and heat-shock factor protein 1), 18 DNA repair (NBS1, PARP1, Ku70, and WRN), 18 and ...

SIRT1 is known to suppress the activity of both NF-kappaB and p53, and since its dysregulation has been associated with models of several aging-related conditions, the research team focused on ...

It activated p53-mediated apoptosis in multiple cancer cell lines. Similarly, studies have demonstrated inhibition of SIRT1 by CCAR2 through enhanced cellular Myc (c-MYC)-induced apoptosis ...

Research investigates the effects of SIRT1 activation through resveratrol supplementation and energy restriction on vascular function in adults. The study reveals that both interventions increase ...

Several mechanisms may account for the effects of SirT1 on inflammation in vitro: SirT1 can induce transcriptional silencing by deacetylating histone 3 at lysine 9 (H3K9) and histone 4 at lysine ...

HO-1 inhibits the activation of the TGF-ß/Smad3 pathway in NAFLD-related liver fibrosis through SIRT1. These findings provide insights into new therapeutic strategies for treating NAFLD ...

To test the impact of a SIRT1-activating drug in depressed mice, Prof. Lu and team knocked out the SIRT1 gene in male rodents and examined their reaction to a sweet drink that they would usually ...