The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase Sir2 (silent information regulator 2) regulates gene silencing in yeast and promotes lifespan extension during caloric restriction.

The function of protein deacetylase SIRT1 in cancer is controversial: it has been shown to have oncogenic properties as well as tumour suppressor activity. How might these opposing functions be ...

Several mechanisms may account for the effects of SirT1 on inflammation in vitro: SirT1 can induce transcriptional silencing by deacetylating histone 3 at lysine 9 (H3K9) and histone 4 at lysine ...

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21. Gastroenterology , 2013; DOI: 10.1053/j.gastro.2013.10.059 Cite This Page : ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Bose, Priyom. (2023, July 03). SIRT1: Unlocking the secrets to better vascular health through ...

According to the researchers, a buckwheat-based diet helps to increase the level of SIRT1 protein that protects all the cells of the body and enhances longevity. In the same time, there is no need ...

Scientists have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division.

SIRT1 has also been shown to interact with LXR to promote LXR activation. Additionally, previous literature has shown that starvation increases SIRT1 levels in mice. The purpose of this study was to ...

HO-1 inhibits the activation of the TGF-ß/Smad3 pathway in NAFLD-related liver fibrosis through SIRT1. These findings provide insights into new therapeutic strategies for treating NAFLD ...

To test the impact of a SIRT1-activating drug in depressed mice, Prof. Lu and team knocked out the SIRT1 gene in male rodents and examined their reaction to a sweet drink that they would usually ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of ...