Walsh and colleagues [26] conducted a 6-month trial comparing the effects of daily doses of 60 mg raloxifene, 120 mg raloxifene, 0.625 CEE plus 2.5 mg MPA, and placebo.

Only 2 SERMs (tamoxifen and raloxifene) are currently available by prescription, and their approved indications are limited; however, a number of newer SERMs are in development.

The most recommended FDA-approved menopause supplements include hormone replacement therapy (HRT) and selective estrogen receptor modulators (SERMs) such as raloxifene.

SERMs, such as raloxifene and bazedoxifene, can also prevent bone loss in postmenopausal women with osteoporosis (LeBoff et al., 2022). PTH analogs, including teriparatide and abaloparatide, act as ...

We searched for studies that used estrogen alone; estrogen in combination with progestogens; synthetic steroids, (such as tibolone); selective estrogen receptor modulators (SERMs, that affect how ...

In women at increased risk for BC, tamoxifen (20 mg/d for 5 years) may be offered to reduce the risk of invasive ER-positive BC, with benefits for at least 10 years. In postmenopausal women, ...

Denosumab belongs to the class of antiresorptive osteoporosis drugs, which also includes bisphosphonates, selective estrogen receptor modulators (SERMs), calcitonin, and hormone replacement therapy.

The hormone receptor (HR) protein, a key component of breast cancer, is used to classify the disease by the presence of these specific receptors -- i.e., proteins in or on cells that can attach to ...

Introduction & Market Context Atossa Genetics Inc (NASDAQ: ATOS) presented its Year-end 2024 business update on March 25, 2025, highlighting progress with its lead drug candidate (Z)-endoxifen ...

Both raloxifene and bisphosphonates are indicated for the prevention and treatment of postmenopausal osteoporosis. Raloxifene increases vertebral BMD and reduces the risk of vertebral fractures in ...

MORE [22,b] (n = 7,705) Multicenter, randomized, double-blind, placebo-controlled 66.5 ± 7 Raloxifene hydrochloride 60 or 120 mg/day or placebo Raloxifene group: 13 women diagnosed with invasive ...

Theoretically, SERMs could be synthesized that would exhibit nearly complete agonist activity on the one hand or pure antiestrogenic activity on the other. Depending on their functional activities, ...