with p107 playing a minor role. Interestingly, p53 WT interacts with both p130 and p107. This is likely due to the cell cycle-regulated expression of p130 and p107, where p130 is predominantly ...

Huttle, 42, of Hobart, Ind., who was sentenced to six months for his role in the riot at the U.S. Capitol in 2021, resisted arrest after he was stopped in Indiana on Sunday. By Michael Levenson A ...

Our work highlights the differing consequences of compartment-specific unfolded protein, particularly in the nucleus, and points to the possible role of p53 in a nucleus ... either wild-type p53 or ...

The p53 tumour suppressor protein has a crucial role in cell‐cycle arrest and apoptosis ... G2–M transition and the IRES for ΔN‐p53 showing highest activity at the G1–S transition. These results ...

The tumor suppressor p53 is well known for its roles in inducing cell cycle arrest, apoptosis, senescence and ferroptosis. Recently, emerging evidence has shown that p53 is also actively involved in ...

A growing number of studies have convincingly demonstrated a paradoxical role ... of p53, the up-regulation of p21WAF/CIP1 and the inhibition of cyclin-dependent kinase, leading to permanent ...

The p53 gene is extremely important in cell biology as its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the “tumor suppressor gene.” However ...

The gene p53 ... role or roles of p53 in pluripotent stem cells is essential," he said. "Our goal was to finally resolve this question of whether p53 is essential for inducing cell cycle arrest ...

Studies have demonstrated p21’s use as a target of p53 activity ... its activation of cell cycle arrest and DNA repair. P21 has been observed to play a crucial role in transcriptional regulation.

Any problems that arise during this replication process can lead to damaged DNA, which can in turn cause growth arrest or ... loss of p53 in cancer cells that lack the G1 checkpoint." ...

They treat an RPE1 Plk4 as cell line with analogue inhibitor to deplete centrosomes and find that cells arrest in G1 with high p53 and p21 levels. This arrest is p53 dependent as previously described ...