TB can be cured, but ridding the body of the bug often takes many months and usually requires taking four or more medicines.

TB can be cured, but ridding the body of the bug often takes many months and usually requires taking four or more different medicines. In this Spotlight special briefing, we zoom in on what makes the ...

TMC207 is a first-in-class anti-TB diarylquinoline (also named R207910 or the 'J' compound) with activity against drug-sensitive and drug-resistant TB. TMC207 inhibits the proton pump of ...

Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with ...

The combined administration of isoniazid and rifampicin changed the oxidant-antioxidant balance in favor of oxidants, and it increased blood urea nitrogen and creatinine levels, which are indicators ...

The main genes associated-mutations conferring drug resistance to rifampicin and isoniazid determined by the GenoType MTBDRPlus V2 on the subset strains (N = 35) were D516V (20%), S531L (20%), H526D ...

AUC0–24 of isoniazid, rifampicin and pyrazinamide along with C max of isoniazid and pyrazinamide on day 10 were higher in patients who developed DILI than those without DILI (p<0.05). Conclusion ...

It also showed additive interactions with Isoniazid and Rifampicin, enhancing their antibacterial effects. Additionally, Ajoene reduced the motility of M. smegmatis, which is crucial for biofilm ...

Multidrug-resistant (MDR) tuberculosis (defined as resistance to both rifampicin and isoniazid) is rising globally.1 In many countries, the diagnostic algorithms in new patients with tuberculosis ...

Figure 2. Rifampicin survival curve in isoniazid susceptible and resistant clinical M. tuberculosis isolates. (A, B) The bacterial kill curve as measured by log 10 survival fraction from data ...