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Like Pol theta, HIV reverse transcriptase acts as a DNA polymerase, but can also bind RNA and write RNA back into a DNA strand. In a series of elegant experiments, the researchers tested ...
Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older. The ...
The enzyme RT of HIV-1 is responsible for copying the viral single-stranded RNA genome to double-stranded DNA (dsDNA ... acid duplex may slide past the polymerase active site 17, and a rearranged ...
Scientists have now created a synthetic reverse transcriptase using directed evolution ... copying RNA into DNA and then amplifying the DNA with a DNA polymerase. But ...
In the latest shake-up for scientific dogma, research has demonstrated that eukaryotic cells can convert RNA sequences back into DNA, through a misunderstood, ‘error-prone’ polymerase. Historically, ...
The reverse transcriptase enzyme that catalyzes this reaction has RNase activity that then degrades the RNA portion of the hybrid. Subsequently, a single-stranded DNA molecule is synthesized by the ...
RT-PCR (reverse-transcriptase polymerase chain reaction): PCR is a method that allows logarithmic amplification of short DNA sequences within a longer, double-stranded DNA molecule. Gene expression ...
The discovery of reverse transcriptase is a story ... a protein called RNA polymerase was involved in reverse-translating RNA to DNA. The discovery was transformative. The prevailing belief ...
The editorial by Bartlett and Starczynski, entitled, "Quantitative Reverse Transcriptase Polymerase Chain Reaction and the Oncotype DX Test for Assessment of Human Epidermal Growth Factor Receptor 2 ...
“The idea of having a motor that you put in reverse sounds very appealing to us, but it's much more efficient to throw the motor out,” Wuite explained. Unlike cars, a cell has multiple DNA polymerase ...
Prior to its release into the nuclease, the covalently bound viral reverse transcriptase/DNA polymerase is removed. The nicked HBV DNA is repaired by the human host cell's DNA repair machinery.
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