Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older. The ...

Exposure to nucleoside reverse transcriptase inhibitors (NRTIs), which treat HIV and hepatitis B and inhibit inflammasome activation, is associated with a significantly lower incidence of Alzheimer ...

Prime editing is an advanced gene editing technology that enables precise DNA corrections without introducing double-stranded breaks, significantly reducing off-target effects. This innovation holds ...

Transposon said its oral small molecule TPN-101 has been selected for testing as part of the HEALEY ALS platform trial.

A UVa researcher has discovered that NRTIs, drugs used to treat HIV, can also help prevent Alzheimer's and a long list of ...

NRTI = nucleoside reverse transcriptase inhibitor, NNRTI = nonnucleoside reverse transcriptase inhibitor, PI = protease inhibitor. b While this has not been reflected in the IAS-USA and BHIVA ...

We report the first use of human telomerase reverse transcriptase (hTERT) expression in experimental xenotransplantation. Previously, we showed that bovine adrenocortical cells can be transplanted ...

Nucleoside reverse transcriptase inhibitor; PI: Protease inhibitor; PK: Pharmacokinetics; RPV: Rilpivirine. Data taken from [10,33–38]. Blake Max's spouse is employed as a regional medical ...

In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse transcriptase (RT) related to group II intron RTs. An RT-Cas1 fusion protein has been recently shown to enable ...

In several type III CRISPR systems, Cas1 is naturally fused to a reverse transcriptase (RT). In the marine bacterium Marinomonas mediterranea (MMB-1), we showed that a RT-Cas1 fusion protein enables ...

School of Pharmacy, National Defense Medical Center, 161 Section 6, Minchuan E. Road, Neihu, 114, Taipei, Taiwan, R.O.C., and Institute of Biopharmaceutical Science ...