New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

With only seven genes, the BK polyomavirus must use the host cell’s DNA replication machinery to produce new viruses. Although the virus was discovered over 50 years ago, little is known about how ...

In the world of viral research, uncovering a virus’s weaknesses is often a painstaking process that requires years of ...

The cold sore-causing Herpes Simplex Virus (HSV-1) hijacks human cells and reconfigures its DNA within just an hour after infection, according to a new study that may help tackle the pathogen.Viruses ...

TAg expression and viral replication occurred after the first round of host DNA replication, and TAg expression also depended on the cell's going through a first round of replication.

Researchers discovered that HSV-1 (herpes simplex virus) actively reshapes the 3D layout of human DNA within hours of ...

New research has discovered that the Herpes virus actually takes control of key RNA functionality and changes human DNA in ...

Scientists in Spain and China discovered that HSV-1 begins rewriting the architecture of human genes just one hour after ...

When they expressed this mutant viral protein in human cells using a system to evaluate polyomavirus DNA replication, they found the virus’s genome replication was decreased by 10-fold. However, viral ...

A chemical method for generating live-attenuated, replication-defective DNA viruses for vaccine development. Cell Reports Methods, 2022; 2 (9): 100287 DOI: 10.1016/j.crmeth.2022.100287; ...

Rutgers scientists have developed a new approach to stopping viral infections: a so-called live-attenuated, replication-defective DNA virus vaccine that uses a compound known as centanamycin to ...

A replication-defective DNA virus is incapable of replicating its genome, its essential genetic matter. As a result, it is unable to produce an infectious progeny virus in infected cells, ...