Angiotensin II binding to AT1 receptors promotes synthesis of transforming growth factor β1 (TGF-β1), which leads to increased protein kinase activity and initiates a cascade of phosphorylation ...

Rats were perfused with fixative, and paraffin sections of the kidneys were processed with antisera against renin (EC 3.4.99.19), AII, and other components of the renin-angiotensin system. Renin ...

In addition, blocking the AT 1 receptor leads to increased levels of plasma renin activity and increased angiotensin II production through loss of feedback inhibition on renin production. [29] ...