Growth of Kym-1 rhabdomyosarcoma cells depends on endogenous receptor tyrosine kinase signals activated by insulin and insulin-like growth factors (IGF), as revealed from enhancement of ...

Fig 1. CONSORT diagram (patient disposition). HER3, human epidermal growth factor receptor 3; PD, progressive disease. Fig 2. Kaplan-Meier plots of (A) PFS and (B) DOR, both by BICR per RECIST 1.1.

Cediranib is an orally available pan-VEGFR tyrosine kinase inhibitor with a half-life of 22 hours compatible with once daily dosing. 15 Cediranib has a subnanomolar 50% inhibitory concentration for ...

Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach vs. avoidance behavior. Mount Sinai researchers ...

These are grouped according to the way they work. For thyroid cancer, doctors use a type of targeted drug called tyrosine kinase inhibitors (TKIs). TKI’s block a cancer cell chemical messenger called ...

have transformed the treatment landscape of unresectable hepatocellular carcinoma (HCC), replacing multi-tyrosine kinase inhibitors (TKIs) as first-line therapies for most patients. Following positive ...

bCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA cDepartment of Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana ...

1Research Institute Children’s Cancer Center Hamburg, Hamburg, Germany. 2Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Hamburg, Germany.