The authors review methodologies to detect post-transcriptional splicing, the mechanisms controlling splicing ... advances have enabled discoveries of RNA polymerase interactions with RNA ...

RNA splicing is a modification of the nascent ... and explore its impacts and mechanisms in the nematode nervous system. Profiling alternative splicing in single cells is challenging due to ...

Surprisingly, this shift did not significantly change global gene activity, but it altered how certain RNA transcripts were processed—a mechanism known as alternative splicing, which enables ...

Unnecessary sequences called 'introns' are removed from gene transcripts. But where do they come from? | Genetics And ...

A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage.

In higher eukaryotes, a vast variety of RNAs is transcribed from genomic DNAs. The transcribed RNAs are subjected to RNA processing steps, such as splicing, ...

CircRNAs are unique RNA molecules formed through a back-splicing mechanism that connects the 5' and 3' ends of precursor mRNA. Previously considered splicing errors, circRNAs are now recognized ...

As the global population ages, the risk of developing neurodegenerative diseases such as dementia, Alzheimer's disease, ...

A new study has shown that old neurons have unique defects from molecular stress that make them vulnerable to ...

Advancements in gene therapy for Duchenne muscular dystrophy (DMD) have improved the outlook for some patients, but further ...

Discover how neurodegenerative diseases may start with blood-brain barrier damage, leading to memory loss and cognitive ...