In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read like a recipe to build a protein. But there's more to the story. Some RNA ...

In conclusion, in-cell SHAPE-MaP enables RNA structure to be examined at single-nucleotide resolution in a native cellular environment, including for RNAs of low to moderate abundance. In-cell ...

Determining the local flexibility as a function of nucleotide position provides important information that enables the sequence and structure of an RNA to be related to its biological function.

"It's relatively easy to discover the nucleotide sequence of an RNA molecule ... having to compare different possible predictions of RNA structure, the scoring function provides a measure of ...

Researchers at Ruhr-Universität Bochum (RUB) describe a way to use AI to reliably predict the structure of certain RNA molecules from their nucleotide sequence in the journal PLOS Computational ...

Inspired by historical work showing that structure plays a role in the function ... decided to investigate which regions of the 600-nucleotide RNA molecule are crucial to its function.

Pseudouridine is an isomer of uracil, meaning it has the same chemical formula but a different structure. It is often referred to as the "fifth nucleotide" due to its abundance in RNA. Pseudouridine ...

Before new discoveries of RNA nucleotide modifications were made, the focus of epigenetics studies was DNA and protein modifications. However, the discovery of what scientists are calling an “extra ...

The integration of high-throughput sequencing technologies, bioinformatics tools, and structural biology approaches will provide a more comprehensive understanding of the complex interplay between RNA ...