A new class of metabolite, with a pyrrole-like structure, has been demonstrated in the tissues of animals poisoned by pyrrolizidine alkaloids. There is some correlation between the degree of ...

Ergot alkaloids are a group of headache medicines that include dihydroergotamine (Migranal, Trudhesa, others) and ergotamine (Cafergot, Ergomar, Ergostat, others). These drugs are used only to ...

More than 3,000 monoterpene indole alkaloids (MTIAs), which are natural ... ring fused with a five-membered nitrogen-containing pyrrole ring. Functionalization at the C5 position of the indole ...

In the realm of organic chemistry, one class of compounds has captured the scientific community's attention for decades - alkaloids. These naturally occurring compounds are known for their diverse ...

‘The pyrrole enabled us to do chemistry which cannot be done ... compared to the 15–20 steps previously reported. For both alkaloids, the Ciamician–Dennstedt rearrangement to create 3-chloropyridine ...

Over 1,000 pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) occur in 3% of all flowering plants. PA-N-oxides are toxic when reduced to their parent PAs, which are bioactivated into ...

Pyrrole disorder develops when there are too many pyrrole molecules in your body. These can strip your system of essential nutrients that play an important role in mood regulation. Doctors don’t ...

The researchers administered a molecular precursor of pyrrolizidine alkaloid with a different structure. Then, they converted it to the active body containing the pyrrole structure near cancer cells ...

“Pyrrolizidine alkaloids only show toxicity when metabolized in the body and converted to their ‘active form’ containing the pyrrole structure. The active form damages the cancer cell’s ...

The scheme of hepatic metabolic activation of retronecine-, heliotridine-, and otonecine-type PAs to form dehydropyrrolizidine alkaloids (DHPAs), which either bind with glutathione as a detoxification ...