Candida auris is a dangerous fungal pathogen that has become a global health concern. It spreads easily in health care settings and can cause life-threatening infections, especially in patients with ...

A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and ...

Pyrimidine compounds acting as ubiquitin carboxyl-terminal hydrolase 1 (USP1) inhibitors and reported to be useful for the treatment of cancer have been disclosed in a recent Asieris Pharmaceuticals ...

After F2G’s first attempt to get a brand-new class of antifungal to market was derailed by the FDA, the U.K.-based biotech has secured $100 million in fresh funding to bankroll another push ...

Garg, S., Kumar, R., Kunimoto, D. and Rayat, G.R. (2022) Anti-Mycobacterial Activity of Flavonoid and Pyrimidine Compounds. Molecules, 27, Article 6714.

Reactions have been discovered that selectively transform nitrogen-containing rings, called pyrimidines, into various other ring systems — enabling rapid preparation of compound libraries for ...

RAPT Therapeutics has been granted a patent for pyrazole pyrimidine compounds that target hematopoietic progenitor kinase 1. The compounds can be used for therapeutic purposes. GlobalData’s report on ...

Shanghai Visonpharma Co. Ltd. has identified pyridine [4,3-d]pyrimidine compounds acting as Toll-Like receptor 7 (TLR7) and TLR8 agonists reported to be useful for the treatment of cancer and viral ...

Nitrogen is a vital component of life and human culture. But today, the majority of the N atoms in synthetic N-containing compounds come from NH3, which is mass-produced using the Haber-Bosch method, ...

To access the pyrimidine-embedded medium/macro- and bridged cyclic compounds with sufficient conformational diversity, we first designed conformationally rigid starting tricycles (1) that were easily ...