Pemetrexed, an folate analogue that inhibits multiple enzymes involved in purine and pyrimidine synthesis (thymidylate synthetase, dihydrofolate reductase, glycinamide ribonucleotide ...

Data also suggested increased formylated folate pool and increased purine synthesis when folate is adequate. The impacts of MTHFR 677T polymorphism appeared closely related to folate status ...

They showed that the SARS-CoV-2 remodels the host folate and one-carbon metabolism at the post-transcriptional level to support de novo purine synthesis for the virus' genome, bypassing the viral ...

A new study describes a core enzyme involved in the synthesis of these building blocks, called purines, and how the enzyme might change during infection by herpes simplex virus. Neuron-like cells ...

This is crucial to prevent the waste of (1) energy and nitrogen, (2) to control the total amounts of purine nucleotides available for nucleic acid synthesis and (3) the purine waste product ...

Guanine is also a component of important biomolecules such as GTP (guanosine triphosphate), which is involved in cellular signaling and protein synthesis. In addition to their role in nucleic acids, ...