likely becomes essential due to impairment of de novo purine synthesis. Other genes with strong environmental lethality or viability included several other players in nucleotide synthesis (DHODH, UMPS ...

For years, researchers have observed reduced uric acid levels in Parkinson's disease patients. Uric acid is created when the... corporate communications solutions . With broad reach and a seasoned ...

By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism and the recycling of adenosine triphosphate (ATP ...

"These questions pointed us straight to purine metabolism," said Wahl, associate professor of radiation oncology and neurosurgery. The findings were published in Cancer & Metabolism. Wahl's team ...

We show that folate depletion induces early blockade of purine synthesis and accumulation of the purine synthesis intermediate and signaling molecule, 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide ...

So does production of melatonin, the hormone that regulates sleep. Folate is a cofactor in the synthesis of nucleic acids and is needed to maintain the integrity of DNA. Additionally, through ...

The folate cycle, which synthesises methyl groups, is essential for many genomic and non-genomic methylation reactions, via S-adenosylmethionine and, indirectly, for the synthesis of purines and ...