Data also suggested increased formylated folate pool and increased purine synthesis when folate is adequate. The impacts of MTHFR 677T polymorphism appeared closely related to folate status ...

Pemetrexed, an folate analogue that inhibits multiple enzymes involved in purine and pyrimidine synthesis (thymidylate synthetase, dihydrofolate reductase, glycinamide ribonucleotide ...

They showed that the SARS-CoV-2 remodels the host folate and one-carbon metabolism at the post-transcriptional level to support de novo purine synthesis for the virus' genome, bypassing the viral ...

This is crucial to prevent the waste of (1) energy and nitrogen, (2) to control the total amounts of purine nucleotides available for nucleic acid synthesis and (3) the purine waste product ...

Guanine is also a component of important biomolecules such as GTP (guanosine triphosphate), which is involved in cellular signaling and protein synthesis. In addition to their role in nucleic acids, ...

So far as is known today, uric acid serves no biochemical function in the body other than being an end product of purine metabolism. The metabolically important purines, adenine and guanine, serve ...

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...

Adverse effects of low-dose MTX in patients with RA are related to folate antagonism and/or folate deficiency. Folate supplementation, in the form of folic acid or folinic acid, is often ...

A new study describes a core enzyme involved in the synthesis of these building blocks, called purines, and how the enzyme might change during infection by herpes simplex virus. Neuron-like cells ...

"These questions pointed us straight to purine metabolism," said Wahl, associate professor of radiation oncology and neurosurgery. The findings were published in Cancer & Metabolism. Wahl's team ...