Free protein S itself has anticoagulant effects: it inhibits the prothrombinase complex (factor Xa, factor Va, and phospholipid), which converts prothrombin to thrombin, and the tenase complex ...

Prothrombinase activity is required for the rapid, ... allowing the prothrombinase complex to function with APC, and (3) inhibiting APC slowly. Clinical trials show low thrombotic risk, ...

Factor Xa, factor Va, and calcium form a prothrombin-activating (prothrombinase) complex, which promotes the conversion of pro-thrombin to thrombin.

New research at the University of North Carolina at Chapel Hill has found that a fatty molecule on the surface of platelet cells is a regulator of blood coagulation. Besides its role in forming ...

(a) The prothrombin complex, consisting of FXa and FVa, catalyzes the conversion of prothrombin to thrombin, leading to coagulation. (b) FXa inhibitors such as rivaroxaban and apixaban bind ...