Through the intrinsic tenase complex (factors IXa and VIIIa) and the prothrombinase complex (factors Xa and Va), the additional thrombin required to down-regulate fibrinolysis is generated by the ...

allowing the prothrombinase complex to function with APC, and (3) inhibiting APC slowly. Clinical trials show low thrombotic risk, with no significant D-dimer elevations, indicating controlled ...

Atherosclerosis is a systemic arterial disease that originally involves the intima (affecting the media and adventitia to a less extent) of large- and medium-size arteries, including the coronary ...

The tenase complex (FVIIIa:FIXa) amplifies the clotting cascade by activation of FX to FXa. The prothrombinase complex (FVa:FXa) activates prothrombin to thrombin, the central protease of the ...