To obtain high-quality structural or functional data, protein purification is typically required, which is both time and resource consuming, especially at the scale required to train ML tools. Here, ...

Abstract: Gene translation is a central stage in the intracellular process of protein synthesis. Gene translation proceeds in three major stages: initiation, elongation, and termination. During the ...

Plaques were analyzed by liquid chromatography–mass spectrometry for the presence of N-terminal fragments ... Identified peptides include signal and pro-peptides from synthesis and those from protein ...

In this work, through stochastic modeling of translation in single mRNA molecules and empirical measurements of protein noise, we show that ribosome demand associated ... We specifically focused on ...

As a ribosome substrate, proline reacts markedly slower when compared with other amino acids both as a donor and as an acceptor of the nascent peptide. Furthermore, synthesis of peptides ... to the ...

The beginning of protein synthesis is carried out by ribosomes ... and contain two different domains called the N and C terminals. The N terminal contains ATPase whilst the C terminal binds ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic ... proteins synthesized in ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal ... in cells by ribosomes. This diverse set ...

The ribosome synthesizes ... the full ankyrin repeat protein architecture we decided to experimentally characterize its folding on the ribosome. The vectorial nature of protein folding in the ...