Protein Coupled Receptor (GPCR) Targeting: Technologies and Global Markets" is expected to grow from $4.4 billion in 2024 to $6.1 billion by the end of 2029, at a compound annual growth rate (CAGR) of ...

Understanding of the functional significance of the wide structural diversity of G-protein-coupled receptors (GPCRs) — one of the most important families of drug targets — has advanced ...

A protein-engineering strategy, in which a constitutively active form of an immune receptor is kept inactive by a peptide ...

New computational tool enables prediction of key functional sites in proteins based on structure Date: September 3, 2020 ... such as G Protein-Coupled Receptor (GPCR) drugs, ...

The GRAFS classification system of G-protein coupled receptors in comparative perspective. Gen Comp Endocrinol. 2005;142(1):94-101. Rosenbaum DM, et al. The structure and function of G-protein-coupled ...

Taste, pain, or response to stress — nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the ...

Viruses and bacteria are always trying to sneak into our bodies, but researchers at the University of Missouri are discovering that our own biology may already hold the keys to fighting off some of ...

Wikimedia Commons, Valeryns The 2012 Nobel Prize for Chemistry goes to Robert J. Lefkowitz of Duke University and Brian K. Kobilka of Stanford University for their work in discovering the inner ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds the host receptor angiotensin-converting enzyme 2 (ACE2). This binding promotes virus membrane fusion and ...

One way to control switching in a protein, such as a nuclear receptor, is to put a drug "in the pocket" of the drug. For her Ph.D. research, Iris van de Gevel looked at controlling two receptors: ...

First to attach is PA, which binds to a receptor protein on a cell. Next, PA is cleaved by an enzyme there. Then, the other two toxin components attach to PA and gain entry into the cell.

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell's demolition ...