The team captured molecular ‘snapshots’ of RNF216 as it assembled chains of the small protein ubiquitin, which tags the target proteins to modify their behaviour in the cell.

WHEN A BABY is born, one of the first things that one wants to do is take pictures of it. But for baby proteins newly biosynthesized on ribosomes, obtaining structural pictures has proved ...

The inset shows the molecular and chemical structure of the protein, miRFP718nano. [Junjie Yao, Duke University] Imaging deep tissues with light is challenging.

When proteins are made in a cell, they start out as strings of amino acids, which have to be folded into the correct, 3D ...

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into ...

More information: Ankur Garg et al, The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs, Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.09.008 Provided by Cold ...

Researchers found a rare example of an ancient protein that can still function in a molecular mirror world – offering new clues about the evolutionary history of proteins that bind to nucleic acids.

Retinol-binding protein 3 (RBP3) is a glycoprotein of about 140 kDa, found in the intercellular space of the retina. It plays an important role in the transport of retinoids—molecules essential ...

Protein-based molecular motors are essential for life. Now, meet 'The Lawnmower' – the first synthetic motor modeled that propels itself by harnessing the energy ... View 3 Images 1 / 3 ...

The ultimate goal—being able to find a molecular glue for any protein target—may still be far off, but systematic approaches for finding glues are yielding new clinical candidates.

A newly designed small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue can help researchers capture deeper, cleaner and more precise biomedical images. ...