The ability of protein kinases to transfer a phosphate group to target proteins plays an important role in many cellular ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

To define the proteins whose expression is regulated by cAMP and protein kinase A (PKA), we used a quantitative proteomics approach in studies of wild-type (WT) and kin- (PKA-null) S49 murine T ...

Keywords: histiocytosis, langerhans cell histiocytosis, mononuclear phagocyte system, CD1a, CD207, langerin, mitogen-activated protein kinase, BRAF inhibitor Citation: Scurtu LG, Scurtu F and ...

Mitogen‐activated protein kinase (MAPK) cascades are important signaling modules regulating diverse biological processes. During the past 20 years, much progress has been made on the functions of MAPK ...

Ryanodine receptor (RyR) phosphorylation by protein kinase A (PKA) may be important in modulating resting sarcoplasmic reticulum (SR) Ca2+ release, especially in heart failure. However, clear cellula ...

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either end of a bone. This process requires the synthesis of extracellular matrix ...

Although the function of the p42/p44 mitogen-activated protein (MAP) kinase pathway in long-term potentiation at hippocampal CA3–CA1 synapses has been well described, relatively little is known ...

Thus, G-protein-coupled receptors can regulate NMDA receptor function indirectly through a PKC-dependent activation of the non-receptor tyrosine kinase (Src) signaling cascade.

A-kinase anchoring proteins (AKAPs) act as molecular scaffolds for a family of functionally related proteins that interact with various signaling molecules, including cyclic adenosine monophosphate ...

A biological system is rich in dynamic biomolecular assembly reaction cascades mediated by enzymes and molecular chaperones, as represented by the formation of the “chain-mail-like” bacteriophage HK97 ...