Protein kinases are responsible for phosphorylations and ... as well as members involved in the three levels of MAP kinase cascades, MAP3K, MAP2K, and MPK. Altogether, these observations resemble the ...

I Biodexa Pharmaceuticals PLC (“Biodexa” or the “Company”) (Nasdaq: BDRX), a clinical stage biopharmaceutical company developing a pipeline of ...

Mitogen-activated protein kinase (MAPK) is an integral component ... To investigate the role of the MAPK cascade in mammalian learning, we determined if learning is associated with activation ...

The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused ...

Protein kinase C (PKC) is a family of serine/threonine kinases that regulates a diverse set of cellular processes including proliferation, apoptosis, cell survival and migration, and there is a ...

† Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical, 26-1 Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8585, Japan ‡ Department of Physics, Graduate ...

Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review ...