Halogenated bisphenol A (BPA) derivatives are extensively utilized in industrial production and have been detected in the environment, as well as in human samples. The 3β-HSDs are important for the ...

In contrast, the synthesis of cortisol requires hydroxylation of pregnenolone by 17a-hydroxylase, which is expressed only in the zona fasciculata and is regulated by adrenocorticotropin (ACTH).

Pregnenolone and dehydroepiandrosterone levels were higher in subjects with schizophrenia and bipolar disorder compared to control subjects in both posterior cingulate and parietal cortex.

These studies used a variety of neurosteroids, including allopregnanolone, pregnenolone and dehydroepiandrosterone (DHEA). "Neurosteroids modulate key neurotransmitter systems, ...