The ELEVATE study compared deupirfenidone, a deuterated form of pirfenidone, with placebo and pirfenidone ... Stapleton said “The mechanism(s) leading to greater mortality [with ganciclovir] are ...

Data from phase II studies also suggest that pirfenidone, which has a different—yet largely unknown—mechanism of action, may also have activity in other fibrosing ILDs with a progressive phenotype, in ...

Nerandomilast is a preferential inhibitor of phosphodiesterase 4B (PDE4B) with antifibrotic and immunomodulatory effects, a mechanism different than approved antifibrotic treatments pirfenidone ...

Although current treatments, such as pirfenidone and nintedanib ... Nanomaterial Examples Advantages Mechanism of Action Applications in Drug Delivery Liposomes Doxil (liposomal doxorubicin) ...

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

Video content above is prompted by the following: How do nintedanib and pirfenidone differ in their mechanisms of action and efficacy in treating IPF?

The scarring of lungs is caused by some unknown origin. The exact mechanism of action of pirfenidone is not known. Pirfenidone is thought to reduce the lung fibrosis (scarring and thickening of ...

Noah M. Merin, MD, PhD, assistant professor at Cedars-Sinai Medicine and medical director of the Hematology and Cellular Therapy Disease Research Group at the Cedars-Sinai Cancer Institute, discusses ...

A research team now describes a new mechanism of action that kills cancer cells through ferroptosis. In a first, a Bochum-based team has produced a substance capable of sending cancer cells into ...

It is currently unknown whether a combination of treatments with different mechanisms of action may be preferable to individual ... Question 7 asked whether patients with SSc-ILD should be treated ...

The scarring of lungs is caused by some unknown origin. The exact mechanism of action of pirfenidone is not known. Pirfenidone is thought to reduce the lung fibrosis (scarring and thickening of ...