This study was performed for the successful detection of biomarkers like Phenylpyruvate and incorporated through paper-based assay using gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs).

Despite the current wealth of sequencing data, one‐third of all biochemically characterized metabolic enzymes lack a corresponding gene or protein sequence, and as such can be considered orphan ...

They demonstrated excessive amounts of tyrosine and p-hydroxy phenylpyruvate in the urine of premature infants receiving a high-protein diet. This effect could be reversed by the administration of ...

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Phenylalanine produced by the arogenate and phenylpyruvate branches are highlighted in purple, isoflavonoids are highlighted in pink, and other phenylpropanoid end products are highlighted in yellow.

Introduction: Heart failure (HF) affects an estimated 6.2 million people in the US, with at least 50% of patients having HF with preserved ejection fraction (HFpEF). Obesity is a risk factor for HFpEF ...

In phenylketonuria high levels of L-phenylalanine are present along with increased levels of phenylpyruvic acid. The present work shows that L-phenylalanine is a competitive inhibitor of human brain ...

Nitisinone capsules are a hydroxy-phenylpyruvate dioxygenase inhibitor indicated for the treatment hereditary tyrosinemia type 1. Credit: Analog Pharma. The US Food and Drug Administration (FDA) has ...

Nitisinone capsules are a hydroxy-phenylpyruvate dioxygenase inhibitor indicated for the treatment of adult and pediatric patients with hereditary tyrosinemia type 1 (HT-1) in combination with dietary ...