The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

At pH 9, FTIR spectra showed the loss of the α-helix structure, indicated by a peak ... to the 2-methylpropyl side chain of the leucine peptide, which decreased in intensity as pH increased.

The specific secondary structure they observed formed a shape called the 310 helix. Because this work was conducted on peptides, the results lend themselves to a greater understanding of electron ...

Three decades ago, chemists created a synthetic family of DNA-like molecules, peptide nucleic acids (PNAs ... ability to unzip and slip inside a DNA helix, making them ideal tools for gene ...

Researchers have created the first supermolecule consisting of a DNA helix and peptide ... they managed to change the chirality of the peptide to match DNA’s right-handedness meaning these two ...

The peptide can then switch back to a helix to fully dock again and activate ... "The pleasure of seeing that Cryo-EM structure and recognizing that there are two states was seeing strong evidence ...

Peptide-based structures can be designed to yield artificial ... oligonucleotide triple helix and a coiled coil protein domain formation have never been realized for de novo protein design.

The double helix structure, the strength of the hydrogen ... The Dresden scientists have analyzed this process for the peptide indolicidin. This antimicrobial protein is less structured and ...

Peptide nucleic acid ... all then at the National Institute of Mental Health, created triple helix structures in which a nucleic acid strand attaches itself in the major groove of a duplex ...