The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

Most proteins are left-handed, but scientists have found an ancient molecule that works in both mirror-image forms.

A molecular reinterpretation of Alice in Wonderland reveals an ancient protein with a surprising function. In a ...

PRISM BioLab is collaborating on new PPI targets with global and Japanese pharmaceutical companies. PepMetics® targeting CBP/beta-catenin PPIs licensed to Eisai Co., Ltd. and Ohara Pharmaceuticals Co.

The effect of conjugated hydrophobic polymers on the peptide secondary and tertiary structures was examined using two types of model, coiled-coil helix bundles. In particular, the integrity of the ...

Figure 1 shows the peptides synthesized and analyzed in this study. BKBL-20 is expected to form higher-order structures through hydrophobic face association in aqueous solution and to interact with ...

Oxidoreductases are key enzymes in biocatalysis, but their dependence on the cofactor nicotinamide adenine dinucleotide ...

Since the COVID-19 pandemic, global interest in antiviral therapies has increased significantly. Recently, with the growing ...

DNA's double helix has long stood as the symbol of life’s code. But buried within the genome lies a deeper level of complexity. One of the more intriguing discoveries in recent years is the i-motif—a ...

Researchers utilized recently published telomere-to-telomere genomes of humans, chimpanzees, bonobos, gorillas, and two orangutans to predict where DNA sequences might form alternative structures ...

What is the best way to drive innovative work inside organizations? Important clues hide in the stories of world-renowned creators. It turns out that ordinary scientists, marketers, programmers ...