The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

A molecular reinterpretation of Alice in Wonderland reveals an ancient protein with a surprising function. In a ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

The effect of conjugated hydrophobic polymers on the peptide secondary and tertiary structures was examined using two types of model, coiled-coil helix bundles. In particular, the integrity of the ...

Oxidoreductases are key enzymes in biocatalysis, but their dependence on the cofactor nicotinamide adenine dinucleotide ...

A new study from the Autonomous University of Barcelona used computational tools to explore more than 100 proteins known as ...

DNA's double helix has long stood as the symbol of life’s code. But buried within the genome lies a deeper level of complexity. One of the more intriguing discoveries in recent years is the i-motif—a ...

Institute of Electronic Structure and Laser, Foundation for Research and TechnologyHellas (FORTH), P.O.Box 1527, 71110 Heraklion, Crete, Greece; and Centre for Self-Organizing Molecular Systems, ...