"It binds to and activates the PPAR δ nuclear receptor. When you turn it on, it promotes cancer. It can stimulate cell proliferation and affect inflammatory pathways," DuBois said.

Once they found that PPAR-gamma was expressed in dendritic cells, the researchers profiled each gene regulated by PPAR-gamma to characterize the pathway leading to NKT activation.

A molecular pathway involving peroxisome-proliferator–activated receptor γ (PPAR-γ) and its downstream effector molecules — the transcription factors STAT5 and HIF-2α and the regulatory ...

Polyunsaturated Fatty Acids from Astrocytes Activate PPAR Gamma Signaling in Cancer Cells to Promote Brain Metastasis. Cancer Discovery , 2019; CD-19-0270 DOI: 10.1158/2159-8290.CD-19-0270 Cite ...

According to a study published online in the journal Cancer Discovery, astrocytes provide fatty acids that activate the PPAR-gamma pathway in cancer cells, enhancing their proliferation.. Brain ...

BB1 treatment activates the toll-like receptor (TLR)-2/TLR-6 signaling pathway, leading to the activation of peroxisome proliferator-activated receptor γ (PPAR- γ).

Tempest Therapeutics Reports Proof of Mechanism Data for First-in-Class PPAR Alpha Antagonist --Compelling preclinical data implicate PPAR as a key metabolic checkpoint for tumor growth-- ...

DEG analysis findings showed 64.0% of genes involved in 428.0 pathways were shared across multiple pathways, with overlap between the Kyoto encyclopedia of genes and genomes (KEGG) and the ...

Previous work by the Evans lab into a gene called PPAR delta ... This means that the PPARD pathway prevents sugar from being an energy source in muscle during exercise, ...

Iqirvo, an oral dual peroxisome proliferator–activated receptor (PPAR) alpha and delta agonist, is the first new drug approved in nearly a decade for treatment of PBC.