In 1992, graduate student Yasumasa Ishida discovered PD-1, marking the beginning of a journey that would make this molecule a ...

Much of our understanding of PD-1’s functions, like many proteins, comes from studies in mice, based on the assumption that rodent and human biology operate similarly. However, human and mouse PD-1 ...

Stuart Tangye, Head, Immunology and Immunodeficiency Lab, Garvan Institute of Medical Research The researchers focused on the molecule PD-1, which acts as a 'handbrake' on the immune system ...

PD-1 deficiency enhances Treg cell pro-tumor function Lim et al. demonstrate that Treg cells deficient in PD-1 occupy key spatial niches within the TME, with regulatory subsets organized near tumor ...

Combination treatment could also benefit patients with lung, bowel, pancreatic and other solid cancers who don’t respond to ...