Duke University researchers have devised a promising, potent pain reliever — seemingly without the harmful side effects and ...

Duke scientists may have discovered a game-changing painkiller. SBI-810 is a new non-opioid drug that offers potent pain ...

Dopamine, a small molecule derived from the amino acid tyrosine, plays a significant role in regulating multiple essential ...

Researchers have taken a closer look at the molecular mechanisms of these active substances. Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the ...

The deal tees up a pain treatment market rivalry with Vertex Pharmaceuticals as the industry starts to move away from opioids ...

differentiating this approach from traditional IBS treatments that primarily target peripheral mechanisms. These findings suggest that opioid delta-receptor activation modulates both peripheral ...

The mechanism here isn’t well-understood, and Ruyle’s work points out the need for a clearer understanding of how opioid receptors throughout the body talk to the brain. He and his coauthors ...

We will test these same ligands for effects against opioid seeking (oxycodone),” he notes. The researchers will incorporate various protocols that allow rats to intravenously self-administer oxycodone ...

The itch sensation can transmit from the skin to the brain via the nerves due to opioids interacting with skin receptors. A third potential mechanism for itch exists if an individual injects drugs ...