Nucleic acid immunity involves a sophisticated set of mechanisms for identifying nucleic acids by immune receptors, playing a vital role in physiological ...

An innovative programmable tool for targeting nucleic acids has been created, utilizing a prokaryotic immune defense system—and it is not CRISPR-Cas. Russian Academy of Sciences researchers have ...

Feb 13, 2024: Researchers discover how functional nucleic acid nanoparticles can effectively deceive the immune system (Nanowerk Spotlight) Since the discovery of the DNA double helix in 1953, ...

Chemoselective transformations that work under physiological conditions have emerged as powerful tools to label nucleic acids in cell-free and cellular environments. However, detailed studies ...

Researchers need to consider targeting exotic, noncanonical nucleic acids—that is, alternative and multistranded DNA and RNA structures. Local transitions in the structure of canonical ds-B-DNA ...

Peptide nucleic acids progress for gene editing and antisense drugs These lab-made molecules can bind to genes more strongly than DNA and RNA do, making them promising drug candidates and genetic ...

If you are studying nucleic acid structures in your lab, you may apply several methods to identify and characterize G4 structures and confirm their formation in your samples.

In single-stranded nucleic acids (both in the virus DNA/RNA genome and in mRNA), “A” bases tend to stack on each other in A-tracts (Bloomfield et al., 2000; McIntosh et al., 2014; Ou et al., 2020): ...