As the cell's molecular control center, the mTor kinase regulates cellular metabolism, growth and division. However, in cells affected by pathological change, the regulation goes awry. Scientists ...

The serine-threonine kinase mammalian target of rapamycin (mTOR) plays a major role in the regulation of protein translation, cell growth, and metabolism. Alterations of the mTOR signaling pathway are ...

mTOR stands for mammalian/mechanistic target of rapamycin. Rapamycin is an immunosuppressant drug that was first isolated from a bacterium found on Easter Island in the mid-20th Century.

Sin1, a mTOR component, is crucial for T lymphocyte maturation, cytokine production, and immune niche regulation. Downregulation of mTORC1 and mTORC2 signaling facilitates antibacterial immunity ...

The PI3K/Akt/mTOR pathway is activated in the majority of pancreatic cancers, and inhibition of this pathway has antitumor effects in preclinical studies. We performed a multi-institutional, ...

Dr Marla Lipsyc-Sharf discusses how to best manage the challenging side effects associated with PIK3CA and mTOR Inhibitors to optimize patient care.