The growing threat of antibiotic resistance highlights the urgent need for new antimicrobial agents. Nonribosomal peptides (NRPs) are potent antibiotics with complex structures, but generating novel ...

What is it? As the name suggests, nonribosomal peptide synthesis (NRPS) generates polypeptides sans ribosome. The resultant peptides, generally short oligomers of two to perhaps 48 residues, are not ...

ABSTRACT: Beauvericin (BEA) is a mycotoxin produced by Beauveria bassiana, through a non-ribosomal peptide synthase, known as beauvericin synthetase (bbBeas). BEA has a wide variety of biological ...

Nonribosomal peptide synthetase (NRPS) enzymes are essential in creating important medications, such as penicillin and cyclosporine. This is done through a multi-step process where the enzymes ...

But there’s a gentler, slightly more under-the-radar alternative out there: Derms also love peptides for their skin-smoothing benefits (namely, their ability to minimize lines without causing ...

Peptidyl compounds produced by filamentous fungi, which are nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs), are rich sources of bioactive ...

Nonribosomal peptide synthetases (NRPSs) are large, multidomain biosynthetic enzymes involved in the assembly-line–like synthesis of numerous peptide natural products. Among these are clinically ...

The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones ...

Many bacteria produce small molecules that can be used as a basis for developing new drugs. The instructions for the pathways that make these molecules are stored in the genome – the complete set of ...

The first decision letter after peer review is shown below.] Thank you for submitting your work entitled "Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase ...