The focus was on understanding how the crystal packing and dimer structures influenced these thermal responses. Their analysis revealed distinct differences between the two crystal types.

Phase 1/2 studies of DZD8586 in CLL/SLL patients after covalent or non-covalent BTK inhibitors and BTK degraders.. If you have the appropriate software installed, you can download article citation ...

Dear Developers, I am currently conducting research on DNA-binding proteins that interact with non-canonical DNA structures. The DNA in question adopts a stacked conformation rather than a traditio ...

Precise quantification of protein-ligand interaction is critical in early-stage drug discovery. Artificial intelligence (AI) has gained massive popularity in this area, with deep-learning models used ...

The overall structure of the MUC5AC-D3 assembly dimer is similar to the previously reported D3 assemblies (Dong et al, 2019; Javitt et al, 2019). The covalent MUC5AC-D3 assembly dimer is formed via ...

The energy landscape will be "flat" for non-covalent systems and there will be many more shallow minima due to the fragments' positions relative to each other. One is at a greater risk of not ...

The structures of the S66 compilation were taken from the original work of Řezáč et al., (81) while the 21 selected ionic H-bonded dimer structures were taken from the IHB100 test set compiled by ...

Researchers from the Institute of Process Engineering of the Chinese Academy of Sciences have developed a sustainable, biodegradable, biorecyclable material: high-entropy non-covalent cyclic ...

The non-covalent molecules DP018 and DP029 exhibited micromolar-level inhibition of GPX4 enzymatic activity (Fig. 4A), comparable to the covalent inhibitor ML162. Surface Plasmon Resonance (SPR) ...

This manuscript describes structures of HER4 homo- and HER4/HER2 hetero-dimer complexes using single particle cryo-EM. This important work convincingly describes new structural details of these ...

The X-ray crystallographic data indicate that the ORF8 dimer contact may function as a non-covalent oligomerization interface (Flower et al., 2021). A loop area between β4 and β5 positioned at 47-83 ...