The success of multiple covalent drugs against proteins once deemed “undruggable” has fueled growing interest in electrophiles that covalently bind amino acids such as cysteine. However, current ...

"OpenAI was founded as a non-profit, is today a non-profit that ... its for-profit arm into a public benefit corporation, a structure designed to balance shareholder returns with social goals ...

Although textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the ...

In this review, we discuss both historical and recent advances (within the past 3 years) in covalent targeting of lysine and tyrosine ... Overly complex ABP structures risk fragmentation and poor LC ...

Medicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, 1117 Budapest, Hungary National Drug Research and Development Laboratory, HUN-REN Research ...

Members from the same GH family are evolutionarily related, show a conserved protein structure and act mechanistically similar ... After blotting, the membranes were incubated in 5% non-fat milk ...

This paper proposes a novel non-uniform frame structure model for power system disturbance propagation analysis. A general state transition model of the power grid is derived from the ...