Figure 1: Mechanism of nucleotide excision repair and base excision repair. The protein factors that are required for TCR and general genome repair (GGR) of DNA damage fall into two broad groups.

A new study uncovers how working at 35,000 feet may disrupt DNA repair and immune function in flight attendants, offering fresh insights into the health risks faced by cabin crews and the urgent ...

The stabilization of DNA repair and stress factors could ... Molecular mechanism of nucleotide excision repair. Genes Dev. 13, 768–785 (1999).

Oxidative stress and DNA damage are also implicated in ... xeroderma pigmentosum complementing protein B; NER, nucleotide excision repair; pol η, polymerase η; SSB, single-strand break; TCR ...

Department of Molecular and Precision Medicine, Penn State College of Medicine, Pennsylvania State University, Hershey 17033, Pennsylvania, United States ...

A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital ...

When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are ...

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized ...

New research from Max Planck Institute reveals how plants defend their genomes from invasion by chloroplast DNA.

Can you briefly explain the concept of replication stress and its role in DNA repair? Liu: It's a really complicated topic. In really broad terms, replication stress is when the process of DNA ...

More information: F. Li et al, Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair, Nature Communications (2025). DOI: 10.1038/s41467-025-59323-y ...