In this study, we investigated the interplay between cigarette smoke, DNA damage and repair, focusing on the Nucleotide Excision Repair (NER) protein ...

NER operates somewhat differently on DNA that is transcriptionally active (transcription-coupled repair) and that which is transcriptionally silent (global genome repair). Defective NER in humans ...

The versatile nucleotide excision repair (NER) pathway removes helix-distorting DNA damage in a multistep 'cut and patch'-type reaction. Two damage detection subpathways exist: global genomic NER ...

Nucleotide excision repair (NER) is a critical DNA repair pathway that plays a key role in maintaining transcription and genome integrity by removing bulky DNA lesions. The key steps in the NER ...

Nucleotide excision repair is a templated DNA-repair pathway that deals with bulky or helix-distorting lesions in DNA, such as ultraviolet (UV) light–induced pyrimidine dimers (interactive graphic).

and then serves as a platform for the assembly of a DNA repair machine called nucleotide excision repair (NER) complex. NER then snips out faulty DNA found and replaces it with an accurate copy.

Scientists have uncovered a critical role for rapid DNA repair in maintaining genome stability. A new study reveals that ...

What is the cellular DNA repair system (NER)? Nucleotide excision repair (NER) genes are responsible for the repair of DNA damage brought about by exogenous agents, such as UV light, chemicals ...

A study has uncovered new findings about a DNA repair pathway called nucleotide excision repair and its role in the development of cancer. The paper also details how this defective pathway could be ...

DNA damage repair is a critical process that all cells need to survive. NER is one of many DNA damage repair processes that attempts to remove UV or chemical-induced DNA damage so that replication ...

DNA damage has emerged as a major culprit in cancer and many diseases related to aging. The stability of the genome is supported by an intricate machinery of repair, damage tolerance, and ...

A parallel process, global genome repair (GGR), was assumed to scan and fix most of DNA independent of transcription. Both processes were thought to set the stage for nucleotide excision repair ...