News

Arialys Therapeutics' precision medicine has shown preclinical potential to address the underlying cause of anti-NMDA ...
Conclusions Paraneoplastic anti-NMDA receptor encephalitis is potentially lethal, but usually reversible if promptly recognized and treated. It should be suspected in young women with prominent ...
In this Case Study, the authors describe paraneoplastic psychosis and catatonia in a patient with encephalitis associated with an immature teratoma of the ovary and NMDA receptor antibodies.
LA JOLLA, Calif., June 17, 2025--Arialys' Nature Communications Paper Supports ART5803 as a First-in-Class Precision Therapeutic for Anti-NMDAR Autoimmune Neuropsychiatric Disease ...
The company is currently completing Phase 1 safety studies for ART5803 and plans Phase 2 evaluation in anti-NMDA receptor encephalitis (ANRE) and autoimmune psychosis patients in the second half ...
Anti-NMDA receptor encephalitis (ANRE) is a rare, potentially lethal, poorly managed, and often misdiagnosed neurological disease. ANRE is caused by pathogenic autoantibodies that bind to and ...
Anti-NMDA receptor encephalitis is a severe brain disorder caused by autoantibodies that trigger NMDA receptor loss. Here, the authors show that ART5803, a monovalent antibody, blocks this process ...
Autoimmunity articles from across Nature Portfolio Autoimmunity is a process by which the immune system reacts against the body's own tissues. Chronic and/or excessive autoimmune responses can ...
1 Introduction NMDA receptors (NMDARs) are widely expressed excitatory ion channel receptors in the brain (Traynelis et al., 2010; Xiong et al., 2025). They typically forms heterotetrameric complexes ...
Memantine selectively improves neural decoding of attended illusory contours, revealing NMDA receptor-dependent enhancement of feedback processing in human visual perception.