Furthermore, targeting the cGAS-STING pathway might not only alleviate liver-specific symptoms but also address systemic metabolic dysfunctions associated with NAFLD. The STING signaling pathway ...

A new study in the Journal of Clinical Investigation provides a link between molecular signaling pathways in the gut, the intestinal microbiome, and development of nonalcoholic fatty liver disease.

Hormone pathway to fatty liver disease uncovered Date: March 21, 2011 Source: ... But without JAK2, the signaling pathway was broken and IGF-1 production was at a standstill.

Furthermore, HO-1 overexpression not only increased SIRT1 expression but also reduced the activity of key regulatory factors in the TGF-ß signaling pathway, suggesting a potential interaction ...

Since TRB3 can block insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance, it may be an important factor in the occurrence and development of NAFLD.

Taking control of this pathway through the Recombination signal binding protein for immunoglobulin kappa J region (Rbpj) protein, the scientists were able to reroute the production of these ...

It is estimated that hepatitis C virus affects approximately 1.3% of the US population and is the leading indication for liver transplantation. About 20% of patients with HCV may spontaneously ...

With an estimated twenty-thousand protein-coding genes in the human genome, pinpointing a specific gene or pathway responsible for a particular disease can be like finding a needle in the ...

The pathway outlines a 4-step screening process for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).